This project is set to identify new homologous enzymes having such unusual product scope, purify them and characterise them based on their substrate and stereoselectivity. A further goal is to determine a protein crystal structure to advance in the mechanistic understanding of these enzymes and to optimise the transformations needed for preparative scale-up in collaboration with industrial partners.

Project information

Workpackage: WP2

Project title: Novel TDP dependent enzymes for the synthesis of tertiary alcohols

Host institution: Albert-Ludwigs-Universität Freiburg

Secondments: Georg-August-Universität Göttingen, University of Zagreb and Johnson Matthey

Supervisor: Michael Müller