This project is focused on researching the structure of the thermostable TK from Geobacillus stearothermophilus, as well as of variants engineered by directed evolution for non-native substrate tolerance. The researcher ESR6 will harness different crystallisation and time-resolved X-ray techniques to perform this task and proceed with protein engineering to further target and design variants with improved activity and selectivity.

Project information

Workpackage: WP2

Project title: Structural origin for novel selectivities of evolved transketolase variants

Host institution: Georg-August-Universität Göttingen

Secondments: TU Darmstadt, Université Clermont-Auvergne and BASF SE

Supervisor: Kai Tittmann