As ESR10, this project is conceived to help identify potential chiral intermediates whose syntheses can be intensified and exploited in industrial sectors such as pharma, agrochemical or fragrances. The researcher ESR11 will recruit known TDP-dependent carboligases for novel applications. Next, they will assess their tolerance for aldehydes and solvents and engineer the enzymes to increase their stability. Finally, they will use the improved catalysts for preparative biocatalysis and progress towards scaling up the process.

Project information

Workpackage: WP2

Project title: Development of solvent- and aldehyde-tolerant TDP-dependent enzymes

Host institution: BASF SE

Secondments: TU Darmstadt and Georg-August-Universität Göttingen

Supervisor: Michael Breuer